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These improvements provide researchers with enhanced tools for studying senescent cell elimination and enable investigation of dose-response relationships and selectivity mechanisms in various experimental models

Together, these results suggest that sleep and sleep deprivation bi-directionally can impact the molecular signalling pathways that regulate synaptic strength and control brain plasticity, supporting the hypothesis of a direct relation between cortical plasticity and sleep regulation ( Figure 4 )

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In addition, it has been demonstrated that these anti-CD38 mAbs also have a potential in vivo immune modulatory effects on the tumor microenvironment such as enhancing effector T-cell function and inhibiting suppressive T-reg activity (42)