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Sertraline as monotherapy caused a significant reduction in the percentage of cells in S phase in the cell line NCI-H125 ( p = 0.0020), which was further confirmed by BrdU incorporation in immunofluorescence stainings ( p = 0.0048) (Supplementary Fig

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This shift was accompanied by increased lean mass in chow-fed male knockouts, suggesting a broader adaptation in body composition that may contribute to enhanced glucose utilization under non-stressed conditions