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However, its function as a therapeutic target for nonneoplastic diseases remains largely elusive

As used herein, a "homologous recombinant animal" is a non-human animal, preferably a mammal, more preferably a mouse, in which an endogenous NOVX gene has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal, e.g., an embryonic cell of the animal, prior to development of the animal

A recent study that investigated the effect of VCN in suppressing the progression of non-alcoholic steatohepatitis (NASH) in mice mentioned that the anti-inflammatory of VCN could be mediated by inhibition of NLRP3 inflammasome activation and hence the NF-B signaling pathway which results in a reduction in the production of pro-inflammatory cytokines 74

In this state, the body begins to break down its own skeletal muscle tissue to harvest amino acids for the immune system and vital organs, a process that rapidly leads to muscle wasting, or sarcopenia