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However, under certain conditions, in the presence of free (unbound) redox metals, such as iron or copper, resulting from metal dyshomeostasis, vitamin C may exhibit prooxidant properties Prooxidant properties of vitamin C in the presence of redox-active metal ions and oxygen have been confirmed predominantly under in vitro conditions, occurrence under in vivo conditions has not been convincingly documented (Halliwell 1996)

Increasing evidence has linked environmental exposures, including trichloroethene (TCE), silica, mercury, pristane, pesticides, and smoking to higher risk for ADs

In general, probiotics that have been shown to effectively lower TMAO levels in human studies are relatively scarce

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