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21 Experimental findings indicate the efficacy of HDAC inhibitors (e.g., hydroxamates (vorinostat), belinostat (PXD101), panobinostat (LBH589) and trichostatin A) for the treatment of neurological disorders, including Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease, spinal muscular atrophy, Rubinstein-Taybi syndrome, and Fragile X syndrome

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Neurological disorders such as AD, PD, glioblastoma, and major depressive disorder present formidable therapeutic challenges due to the highly selective and restrictive nature of the BBB

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