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As expected, the strictly conserved Asn419 hTrxR1 appears to be the most important residue for aligning the flexible C-terminal arm during catalysis, because a simultaneous mutation of all three guiding bar residues (Trp407 hTrxR1 , Asn418 hTrxR1 , and Asn419 hTrxR1 ) led only to a minor increase in hTrx1- and DTNB-reduction activity of hTrxR1 compared to the mutation of Asn419 hTrxR1 alone (Table 2)

Xiong et al., 2018

In one study, medical records of over 173,000 subjects who were prescribed a PPI drug were compared to more than 20,000 who were given a different class of heartburn drugs, known as H2-blockers

Lv J, Song X, Luo Z, Huang D, Xiao L, Zou K