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These symptoms most often include: Paresthesia: Numbness, itching, burning, or tingling in the limbs or other parts of the body Ataxia: impaired coordination, balance, and speech Myelopathy: pain in the neck or back and tingling, numbness, or weakness in the limbs The occurrence of these conditions in people with vitamin B12 deficiency is due to the role of vitamin B12 in preventing nerve damage and ensuring efficient transmission of nerve impulses

However, hemodynamic abnormalities, such as those caused by hypertension or extreme stress, can lead to extracellular matrix injury and the rupture of the basement membrane

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Meanwhile, ATP detection assays confirmed that the ATP level in GGCT-knockdown cells was significantly reduced and rescued in sodium pyruvate or JX06 treatment groups (Fig