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Cytosolic GPx4 is essential for embryonic development and cell survival

The British Journal of Dermatology

Both ME2-inhibitor complexes (ME2-EA and ME2-MDSA) were generated in the presence of the cofactors NAD + and Mg 2+ , the natural substrate pyruvate (PYR), and the inhibitor (EA or MDSA), but the structures demonstrate that only the inhibitor (EA or MDSA) binds to the allosteric regulatory site at the dimer interface (Figs