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Gandhi PU, Gaggin HK, Sheftel AD et al (2014) Prognostic usefulness of insulin-like growth factor-binding protein 7 in heart failure with reduced ejection fraction: a novel biomarker of myocardial diastolic function

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Studies show that the increased fat burning associated with fragment 176-191 directly correlates with energy expenditure and thus weight reduction, leading to a nearly 50% reduction in weight gain in obese animals over a three-week course [4]

The primary mechanism involves intrinsic factor binding in the stomach, while a secondary pathway allows small amounts to absorb through passive diffusion