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SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized patients

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

Frequency varies based on individual needs, but weekly or biweekly sessions are common for optimal results

In the present review, we have focused on the six areas where we work (lung diseases, poisoning, CNS disorders, cardiovascular disease, CIN, and ophthalmologic conditions), while we invite the readers to consult a recently published systematic review of the literature concerning the therapeutic use of NAC in medicine [9], for a comprehensive view of the topic