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As an important regulator of Wnt transduction in the canonical signaling pathway in tumours, Dickkopf-related protein 3 (DKK3) negatively regulates aerobic glycolysis [HK2, HIF-1, GLUT-1, LDHA and 3-phosphoinositide-dependent protein kinase-1 (PDK-1)] in BxPC-3 cells

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Given that GSH and GSSG are also differentially regulated between the plasma and circulating cells (156, 157), these findings also underscore the need for compartmentalized ( i.e ., plasma or erythrocyte vs