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Chromatographia 68:855859

In experimental AP, activation of PINK1/Parkin-dependent mitophagy has been associated with inhibition of NLRP3 inflammasome signaling and attenuation of inflammatory activity in PACs ( Electron microscopy studies have demonstrated that, as early as 12 hours after AP induction, numerous autophagosomes and autophagolysosomes containing mitochondrial remnants appear in PACs, indicating rapid activation of mitophagy (36)

65 Thus, the G6PD A variant, once thought to be a single homogeneous mutation in Africans, now turns out to represent at least three different genotypes

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