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In the case of cancer, this process has a dual activity, since it is capable of promoting the survival of cancer cells, through protective autophagy, or participating in the death of these cells, inducing cytotoxic autophagy (116, 117)

Annu Rev Pathol (2011) 6:395423

Furthermore, DIM inhibited mouse double minute 2 homolog (MDM2) in colorectal cancer cell lines, inhibiting cell proliferation and inducing cell cycle arrest and apoptosis [123]