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When appropriately induced, trained immunity is protective against infection and tumors, and reinforces tissue repair upon acute damage 14,16,17,18,19,20,21 , but its maladaptation leads to chronic inflammatory pathologies and hinders tissue repair after repetitive damage 11,19,22,23,24,25,26,27,28,29

Alterations as small as15 mV in the redox potential can result in transcription factor translocation and activation or deactivation, depending on the direction of the redox shift [36], [37], [38]

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