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This is rare given the peptide occurs naturally in your body, but it happens

doi: 10.1007/s002650050276 42 Institute, SAS (2015)

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This oxidation process was reported to be pH-dependent, with peak transformation at pH = 8, and catalyzed by cyclooxygenase-2 (COX-2) ( Furthermore, the co-addition of redox-active antioxidants (like ascorbate, TBHQ, and Trolox) dramatically increased curcumin stability, expanding its activities