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Additionally, PD caused histological damage indicative of apoptosis and downregulated of the PI3K/Akt signaling pathway, indicating continuing apoptosis

The following section describes the interplay of oxidative stress, neuroinflammation, and intraocular pressure before presenting the three neuroprotective strategies to support the optic nerve

Treating the underlying cause: For secondary carnitine deficiency, addressing the underlying condition, managing kidney disease, treating intestinal disease, improving diet, is as important as supplementation