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Hormones (Athens, Greece) 9 (2), 118126

The observations that dsRNA is not merely an RNAi substrate and can activate signaling pathways as a PAMP and that Dcr-2 and Ago-2 are pleiotropic genes invite detailed analysis with respect to the effects of administration of dsRNA to insect pests and to what extent a bona fide RNAi mechanism is triggered