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Because both pathogens target physical barriers and components of the immune system, their combined presence may result in synergistic pathogenic effects (Warne et al., 2010)

Overall, ROS exacerbate viral infection-induced chronic hepatitis, contribute to liver fibrosis and cirrhosis, and promote HCC growth and metastasis (Fig

Interestingly, the introduction of the R175H mutation in these cell lines yields variable results

Dose and route selection of GEN, NaS, and CCM In the current study, GEN was intraperitoneally injected at 120 mg/kg bwt This dose has been chosen based on several earlier studies that confirmed the GEN ototoxic effect at this dose, route, and duration of exposure (Sagit et al