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While the medulla is hyperosmolar to concentrate urine, its restricted blood supply results in a naturally hypoxic state

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*Correspondence: Yulong Yin, [email protected] Deng, [email protected] These authors have contributed equally to this work This article was submitted to Microorganisms in Vertebrate Digestive Systems, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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