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Crucially, this predictive value was only evident in the BEV treatment group and disappeared in the cytotoxic drug-only treatment group, suggesting MMP-2 is a predictive biomarker specific to BEV efficacy (64)

2.5 Potential biomarkers of ferroptosis Translating ferroptosis from a mechanistic concept into a clinical tool for IPF will require reliable, minimally invasive biomarkers that reflect iron overload, lipid peroxidation, and antioxidant failure in the lung

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Research protocols with documented outcomes consistently use 46 hoursdeviations reduce consistency and magnitude of metabolic improvements