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Techniques of underwater intervention: means, methods, research and outlook

This leads to opening of the mitochondrial permeability transition pore (mPTP), a non-selective channel whose prolonged activation collapses the proton motive force, dissipates mitochondrial membrane potential (MMP), uncouples OXPHOS, and induces cristae remodeling and mitochondrial swelling

MR-PRESSO applies a leave-one-out approach to identify the genetic variant(s) differentially driving the associations [41], i.e., outliers, and provide a corrected estimate after removing the outliers [42]