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However, despite these studies showcasing the bioactivity of catechins, their clinical efficacy may be limited due to their low bioavailability in vivo

Science 287 , 20072010 (2000)

Cells were transferred to 0.5 mL sonication tubes and lysed using a Q800R3 Sonicator (QSonica, 3 cycles at 50% amplitude, 20 seconds ON, 20 seconds OFF, at 4 C)