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Nine randomized controlled trials (RCTs) revealed no evidence of adverse effects of rhGH on estimated GFR (eGFR) over treatment periods of up to 2 years in children with CKD stages 24 [171]

In a randomized, double-blind, placebo-controlled, crossover study, 24 subjects (12 patients with CKD and 12 matched healthy subjects) received pyroglutamated apelin-13 ([Pyr 1 ]apelin-13, 1 nmol/min and 30 nmol/min) or matched placebo on two separate visits

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The International Journal of Developmental Biology, 62 (6-7-8), 491-505