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The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

Anthocyanins are located in the skin and responsible for the blue pigmentation and some associated health benefits

Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via AMPK/PI3K/AKT-mediated oxidative stress

DOX was analyzed using a C18 column (150 4.6 mm, 5 m) with a mobile phase of acetonitrile/0.1% phosphoric acid (30:70, v/v) at a flow rate of 1.0 mL/min, 25 C, and a detection wavelength of 480 nm (injection volume: 20 L)