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This minimum requirement becomes the de facto standard

It is already known that silica-based systems have lower scratch resistance since it is very easy to scratch off the top of larger particles in the film (due to roughness and less mechnical resistance)

J Neurosci Res 86(2):306316 Xiao Y, Li C, Gu M, Wang H, Chen W, Luo G, Yang G, Zhang Z et al (2018) Protein disulfide isomerase silence inhibits inflammatory functions of macrophages by suppressing reactive oxygen species and NF-B pathway