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Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing

Typical experimental endpoints include measures of collagen and extracellular matrix protein expression, cell migration rates, cytoskeletal organization, and transcriptional changes in genes related to tissue structure and repair, depending on the model

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When we run IGF-1 on these patients at intake, the labs confirm what they reported: no meaningful elevation from baseline, no evidence the pituitary responded to the therapy at all