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They are both substrates and inhibitors/inducers of drug-metabolizing enzymes and drug transporters, making them victims and perpetrators of drugdrug interactions (DDIs) [1,2,3]

Building condition-specific metabolic models Condition-specific genome-scale metabolic models (GSMMs) for control and residual tumors from in vivo Palbociclib and Telaglenastat treatments were reconstructed from the human GSMM Recon3D [55]