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All animal experiments were approved by the Institutional Animal Care and Use Committee of China Medical University and performed in accordance to the Guide for the Care and Use of Laboratory Animals (Ministry of Science and Technology of China, 2006) and the related ethical regulations of our university

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We find that acute and short-term treatment of diseased CSMN with NMN not only improve their neuronal health, but also help mitochondria to regain the integrity of their inner membrane