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Glutathione has the potential to make a significant difference

This analysis suggested that ASXL1 itself could be a transcriptional target of BRD4 and pointed to a possible feed-forward mechanism that would explain the high correlation of ASXL1 and BRD4 in malignancies, particularly in glioblastoma

For example, Haran et al

This accumulation of 2,3-BPG shifts the oxyhemoglobin dissociation curve to the right, leading to better oxygen delivery to the tissue and improved tolerance of anemia than would be otherwise expected