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Data were expressed as permeability (Papp) calculated using the following formula: where dQ/dt, rate of permeation C 0 , initial concentration of compound A, area of monolayer (0.11 cm 2 ) Efflux Ratio (R e ) was calculated using the formula: 5.2

This vitamin shortage can happen for a few reasons: when your body cannot take in vitamin B12 from food because of a condition called pernicious anemia, when you have certain illnesses or infections, or take certain medicines that stop your body from absorbing enough vitamin B12 from what you eat, or when you follow a vegan diet which means you do not eat any animal products, like meat, dairy, or eggs

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One of the important components B12 helps synthesize is myelin, which supports nerve functionality and repair after nerve damage