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Molecular functions of the protein products of genes with altered expression under Semax treatment The grouping of the genes according to the molecular functions of their products and to the iReport Web tool revealed that the expression of transcription regulator genes was predominantly enhanced, and that that of genes encoding transmembrane receptors, transport proteins, and various enzymes was decreased 3 h after the onset of ischemia under Semax treatment (Figure 2A)

For toxicokinetic analysis of rat and monkey data, each animal was analyzed separately and results for each dose group were summarized as mean value and no formal statistical analysis was performed to determine the significance of the difference among the exposure groups