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Conflict of interest AS, YS, AG, EC, NT, and JO were employed by Process Research and Development, Merck & Co., Inc

INTRODUCTION Pancreatic cancer is a lethal malignancy with a five-year survival rate of 3%-5%[1,2]

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Posttranscriptional aspects of polyamine-mediated gene regulation are associated with the eukaryotic translation initiation factor 5A (eIF5A), whose expression/function is strongly correlated with unfavorable prognostic implications for several cancers 73,74,75