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Description

In OA, elevated ROS levels contributed to inflammatory cytokines overproduction, reduced synthesis of extracellular matrix (ECM), and enhanced chondrocyte apoptosis, which collectively promotes cartilage degradation 5,10

The kratom indole alkaloids speciociliatine, speciogynine, mitraciliatine, paynantheine, and isopaynantheine were isolated and purified from commercial kratom products as described 3,5

Additionally, in animal studies, RADA16-I (Ac-(Arg-Ala-Asp-Ala) 4 -NH 2 ) with GHK and KGHK (H-Lys-Gly-His-Lys-OH) sequences was found to promote wound healing 13