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Despite the biases and limitations, generating additional hypotheses regarding the pathophysiology of CVS is the main reason for our genome-wide post-analysis

Rose et al., 2012)

However, both recommendations are tempered by statements that the benefits from duloxetine are limited, and that the treatment is more effective in CIPN due to platinum-based therapies than in CIPN caused by taxanes (Loprinzi, Lacchetti 2020

Certainly, we may have missed a gene or mechanism completely outside of the current hypotheses of the pathophysiology of CVS, as in-depth variant analysis throughout the entire genome is far beyond the scope of this study