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Chelerythrine Inhibits the Sarco/endoplasmic Reticulum Ca(2+)-ATPase and Results in Cell Ca(2+) Imbalance

A pivotal shift occurred around 2004 with the discovery of small-molecule E3 ligase ligands [46], culminating in 2008 when Crews team developed the first small-molecule PROTAC targeting AR using an MDM2 inhibitor, formally coining the term PROTAC and establishing its drug-like potential [47]

Curcumin and EGCG improved symptoms such as mucositis, dermatitis and esophagitis, while glutathione-enhanced treatment compliance but did not provide significant protection against side effects

Elevating NAD + levels can increase lipolysis and reduce body weight