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Occasionally the low-density 1.077 g/ml iodixanol layer is replaced with a routine commercial peripheral blood mononuclear (PBMC) isolation medium such as Lymphoprep

The effect could be due to a possible interference with the absorption of cyclosporine, as a lipophilic substance that it is

To ensure the generalizability and reliability of these models, researchers employ validation techniques such as cross-validation and external validation