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Description

A small placebo-controlled study evaluated intranasal 1% Semax with imaging performed minutes after dosing

Critical subgroups at high B12 deficiency risk: patients on metformin (the most prescribed diabetes drug, which blocks B12 absorption in the gut up to 30% of long-term metformin users become B12 deficient)

The enrolled patients were randomized to Group A (carvedilol + ivabradine) and Group B (carvedilol alone) &were assessed every 6m for LV systolic and diastolic function per 2020 CCM criteria