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Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke

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In rats, given a MeHg dose of 0.1 mol/kg (21.4 g/kg), increasing the dose of acetylcysteine from 0.25 mmol/kg (40.5 mg/kg) to 1.5 mmol/kg (244.8 mg/kg) showed a near linear increase in mercury elimination, from 2% of total dose eliminated in 2 h to 10% of total dose eliminated in 2 h, respectively, compared with 0.1% elimination in controls (MeHg + but no acetylcysteine) [Citation34]