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In cholesterol-fed rabbits, supplementation with L-aspartate and L-glutamate has been shown to inhibit the thickening of the aortic intima and the development of liver injury (139)

65,66 Additionally, caspase-1 activation leads to programmed cell death known as pyroptosis, characterized by cell swelling, membrane rupture, and the release of proinflammatory intracellular contents

We break down the core principles that underpin early warning systems, before focusing on how these frameworks are applied to drug early warning systems aimed at identifying emerging substances and harms

The canonical notch signaling pathway: unfolding the activation mechanism