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10 Conclusions Despite numerous research studies and resources invested, the question of what determines the transition from pharyngeal colonization to IMD, which has been raised since Weichselbaums meningococcus, the main agent of epidemic cerebrospinal meningitis, was identified (Weichselbaum, 1887), remains without a definitive answer

An unlicensed medicinal product should not be supplied where an equivalent licensed medicinal product can meet the special needs of the patient

The abundant ROS produced by MLPGA interfered with the transcription of genes related to antioxidants, extracellular polysaccharides, iron ions related pathway, biofilm development and virulence

Realistic expectations essential, maintaining remaining vision versus expecting major improvements