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They're more invasive and they can be painful

Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment

doi:10.1111/j.1479-8425.2007.00262.x Bannai M, Kawai N

In terms of variant evaluation, while SLC22A5, CPT-1 and CPT-2 variants were successfully detected, no pathogenic variants were found in SLC25A20 within the study cohort