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4.2 Evidences of CBD to control oxidative stress CBD has been shown to lessen oxidative metabolism in polymorphonuclear leukocytes and nucleus pulposus cells that have been exposed to H 2 O 2 , and numerous research have suggested that CBD possesses antioxidant capabilities (83, 84), and moreover lowers pancreatic cell oxidative stress markers (85)

These effects have been particularly relevant in neurodegenerative conditions and metabolic disorders, where mitochondrial dysfunction plays a central role

380 An experimental model fed with diet lack of prebiotic fiber induces hypertension through inducing deficiency of SCFA production and GPR43/109A signaling, suggesting the underlying mechanisms of dietary fiber