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21 that utilized a similar crossover design and demonstrated a significantly smaller reduction of mean 17-item Hamilton Depression Rating Scale (HAM-D) scores for a naltrexone-plus-ketamine compared to a placebo-plus-ketamine condition at day 1 postinfusion in individuals with treatment-resistant depression ( n = 12) with a similar effect size ( d = 0.7) to that found in this study ( d = 0.6)

In cell and tissue models, Epithalon upregulates telomerase activity, maintains telomere length, and modulates aging-related gene expression (p16, p21) to delay senescence

As such, any clinical use should be framed as exploratory and hypothesis generating rather than standard of care

A is generated through sequential cleavage of amyloid precursor protein (APP) by -secretase 1 (BACE1) and -secretase (Guillemot et al., 2013)