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This is in line with the antigen-specificity of the response promoted by peptide immunotherapy, and resulted in the suppression by the pCons-induced T regs of the proliferation of CD4 + CD25 - T effectors cells and reduced production of proinflammatory cytokines

The disorder is classified into two main subtypes: bipolar I disorder (BP-I), defined by the presence of at least one full manic episode, and bipolar II disorder (BP-II), characterized by hypomanic episodes without progression to full mania (Grande et al., 2016)