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Tan et al., reported that FIIN-2, an irreversible covalent FGFR inhibitor, formed the covalent binding mode at the Cys477 residue of FGFR4 in the DGF-out conformation (96)

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Kempuraj D, Thangavel R, Selvakumar GP, Zaheer S, Ahmed ME, Raikwar SP, Zahoor H, Saeed D, Natteru PA, Iyer S, Zaheer A (2017) Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration