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on 38 observational cohort and casecontrol studies, only 29.1% of melanomas likely arose from a preexisting nevus and 70.9% arose de novo (54)

More recently, theobromine displayed a preventive effect against interleukin (IL)-1-induced chondrocyte dysfunction through the reduction in the IL-1-induced production of cellular ROS and inflammatory mediators, including ciclooxigenase 2 (COX-2), prostaglandin E2, and NF-KB [217]

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