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When injected directly into the affected area, such as a joint or soft tissue, corticosteroids interact with cells receptors

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For example, cystine availability in cancers is limited that the TSS pathway is activated to provide an alternative source of cysteine 16

conversely, in multiple myeloma (MM), MDSCs induce tumor cell autophagy via AMPK phosphorylation, upregulating MCL-1/BCL-2 expression to enhance MM cell survival (111)