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Alterations in NAD metabolism are critically linked to neurodegenerative disorders, as the accumulation of nicotinamide mononucleotide exerts pro-degenerative effects on axons, whereas enhancing its metabolism may rescue axons from degeneration (53)

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Sansone is a professor in the Departments of Psychiatry and Internal Medicine at Wright State University School of Medicine in Dayton, Ohio, and Director of Psychiatry Education at Kettering Medical Center in Kettering, Ohio

4.1.2 Injectables and CNS-targeting nanotherapeutics for neurodegenerative disease 4.1.2.1 Injectable cytokine releasing hydrogels Injectable hydrogels formed from natural polymers can encapsulate and gradually release anti-inflammatory cytokines at CNS sites, creating a confined immunoregulatory niche