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-Synuclein, a protein typical of Parkinsons disease, is synthesized in the intestines and then carried to the central nervous system via the vagus nerve [95, 110, 111]

Natural materials, including silk fibroin (Zeng et al., 2014), fibrin (Huang et al., 2010), ECM (Yuan et al., 2022), alginate (Huang et al., 2011), and chitosan (Roughley et al., 2006) have demonstrated with biocompatibility and minimal cytotoxicity