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Lipid metabolism Although MDSCs predominantly rely on glycolysis and OXPHOS as a bioenergetic source, lipid uptake and catabolism via fatty acid oxidation (FAO) are now recognized as central metabolic programs that enable MDSCs to survive, expand, and exert potent immunosuppressive functions in the TME (72)

N-acetyl cysteine (NAC) when taken orally, loses the N- acetyl in the stomach, thereby leading to uncontrolled oxidation and a range of toxicities in humans

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The reaction mixture contained 100 L of enzyme extract, 1,900 L of 50 mM phosphate buffer (pH 7.8), 9.9 mM L-methionine, 57 M NBT, 0.0044% riboflavin, and 0.025% Triton X-100